Type 1 diabetes pathogenesis - Prevention???
نویسندگان
چکیده
منابع مشابه
Prevention of type 1 diabetes.
This article discusses type 1 diabetes mellitus, which results from insulin deficiency caused by autoimmune destruction of the insulin-producing beta-cells in the pancreatic islets of Langerhans. The autoimmune response against islet beta-cells is believed to result from a disorder of immunoregulation. According to this concept, T lymphocytes (T cells) autoreactive to certain beta-cell constitu...
متن کاملPrevention of type 1 diabetes.
Prevention of loss of b cells in type 1 diabetes is a major goal of current research. Knowledge of the genetic susceptibility, increasing ability to predict who may be at risk, recognition of the potential clinical impact of residual insulin secretion after diagnosis, and development of new immunomodulatory agents have supported an increasing number of clinical trials to prevent b-cell loss. In...
متن کاملPrevention of type 1 diabetes.
INTRODUCTION/BACKGROUND Type 1 diabetes is a chronic autoimmune condition characterized by destruction of insulin-producing β cells within the pancreatic islets. It is associated with considerable morbidity and mortality. Incidence levels are rising worldwide. SOURCES OF DATA Pubmed search (Nov 2010) using keywords: Type 1 diabetes, prevention, trials, immunotherapy. AREAS OF AGREEMENT The ...
متن کاملOn type 1 diabetes mellitus pathogenesis
Type 1 diabetes mellitus (T1DM) results from the autoimmune destruction of β cells of the endocrine pancreas. Pathogenesis of T1DM is different from that of type 2 diabetes mellitus, where both insulin resistance and reduced secretion of insulin by the β cells play a synergistic role. We will present genetic, environmental and immunologic factors that destroy β cells of the endocrine pancreas a...
متن کاملPathogenesis of type 1 diabetes: genetics
There has been much progress in the identification of genes and molecular pathways involved in the pathogenesis of type 1 diabetes. Human histocompatibility (HLA) complex genes are the most powerful susceptibility determinants. The stronger effect is from alleles coding for selected HLA class I and class II antigen-presenting molecules, which are restricting elements for autoreactive CD8 and CD...
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ژورنال
عنوان ژورنال: Indian Journal of Endocrinology and Metabolism
سال: 2015
ISSN: 2230-8210
DOI: 10.4103/2230-8210.155404